[HTML][HTML] Identification of constitutively active interleukin 33 (IL-33) splice variant
J Hong, S Bae, H Jhun, S Lee, J Choi, T Kang… - Journal of Biological …, 2011 - ASBMB
IL-33/IL-1F11 is a new member of the IL-1 family ligand and provokes T helper-type immune
responses. IL-33 is the ligand of ST2 and IL-1 receptor accessory protein (IL-1RAcP) that
triggers nuclear factor-κ light chain enhancer of activated B cells (NF-κB) and MAPK
signaling. We discovered a novel short splice variant of IL-33 that was termed spIL-33. The
new spIL-33 lacks exon 3 containing a proposed caspase-1 cleavage site. We isolated spIL-
33 cDNA from the Huh7 human hepatocarcinoma cell line and expressed the recombinant …
responses. IL-33 is the ligand of ST2 and IL-1 receptor accessory protein (IL-1RAcP) that
triggers nuclear factor-κ light chain enhancer of activated B cells (NF-κB) and MAPK
signaling. We discovered a novel short splice variant of IL-33 that was termed spIL-33. The
new spIL-33 lacks exon 3 containing a proposed caspase-1 cleavage site. We isolated spIL-
33 cDNA from the Huh7 human hepatocarcinoma cell line and expressed the recombinant …