IL-33 is more potent than IL-25 in provoking IL-13–producing nuocytes (type 2 innate lymphoid cells) and airway contraction
JL Barlow, S Peel, J Fox, V Panova… - Journal of allergy and …, 2013 - Elsevier
Background IL-25 and IL-33 belong to distinct cytokine families, but experimental mouse
studies suggest their immunologic functions in type 2 immunity are almost entirely
overlapping. However, only polymorphisms in the IL-33 pathway (IL1RL1 and IL33) have
been significantly associated with asthma in large-cohort genome-wide association studies.
Objective We sought to identify distinct pathways for IL-25 and IL-33 in the lung that might
provide insight into their roles in asthma pathogenesis and potential for therapeutic …
studies suggest their immunologic functions in type 2 immunity are almost entirely
overlapping. However, only polymorphisms in the IL-33 pathway (IL1RL1 and IL33) have
been significantly associated with asthma in large-cohort genome-wide association studies.
Objective We sought to identify distinct pathways for IL-25 and IL-33 in the lung that might
provide insight into their roles in asthma pathogenesis and potential for therapeutic …