[HTML][HTML] GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 …
Y Baba, K Maeda, T Yashiro, E Inage… - Journal of Biological …, 2012 - ASBMB
The IL1RL1/ST2 gene encodes a receptor for IL-33. Signaling from IL1RL1/ST2 induced by
IL-33 binding was recently identified as a modulator of the Th2 response. The target cells for
IL-33 are restricted in some hematopoietic lineages, including mast cells, basophils,
eosinophils, Th2 cells, natural killer cells, and dendritic cells. To clarify the molecular
mechanisms of cell type-specific IL1RL1/ST2 expression in mast cells and basophils,
transcriptional regulation of the human IL1RL1/ST2 promoter was investigated using the …
IL-33 binding was recently identified as a modulator of the Th2 response. The target cells for
IL-33 are restricted in some hematopoietic lineages, including mast cells, basophils,
eosinophils, Th2 cells, natural killer cells, and dendritic cells. To clarify the molecular
mechanisms of cell type-specific IL1RL1/ST2 expression in mast cells and basophils,
transcriptional regulation of the human IL1RL1/ST2 promoter was investigated using the …