Association of IL33–IL-1 receptor–like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood
OE Savenije, JMM John, R Granell, M Kerkhof… - Journal of Allergy and …, 2014 - Elsevier
Background Genome-wide association studies identified IL33 and IL-1 receptor–like 1
(IL1RL1)/IL18R1 as asthma susceptibility loci. IL33 and IL1RL1 constitute a single ligand-
receptor pathway. Objective In 2 birth cohorts, the Prevalence and Incidence of Asthma and
Mite Allergy (PIAMA) study and Avon Longitudinal Study of Parents and Children (ALSPAC),
we analyzed associations of longitudinal wheezing phenotypes and asthma with single
nucleotide polymorphisms (SNPs) of 8 genes encoding IL-33, IL1RL1, its coreceptor …
(IL1RL1)/IL18R1 as asthma susceptibility loci. IL33 and IL1RL1 constitute a single ligand-
receptor pathway. Objective In 2 birth cohorts, the Prevalence and Incidence of Asthma and
Mite Allergy (PIAMA) study and Avon Longitudinal Study of Parents and Children (ALSPAC),
we analyzed associations of longitudinal wheezing phenotypes and asthma with single
nucleotide polymorphisms (SNPs) of 8 genes encoding IL-33, IL1RL1, its coreceptor …