Bcl6 and Blimp1 reciprocally regulate ST2+ Treg–cell development in the context of allergic airway inflammation
B Koh, BJ Ulrich, AS Nelson, G Panangipalli… - Journal of Allergy and …, 2020 - Elsevier
Background Bcl6 is required for the development of T follicular helper cells and T follicular
regulatory (Tfr) cells that regulate germinal center responses. Bcl6 also affects the function of
regulatory T (Treg) cells. Objective The goal of this study was to define the functions of Bcl6
in Treg cells, including Tfr cells, in the context of allergic airway inflammation. Methods We
used a model of house dust mite sensitization to challenge wild-type, Bcl6 fl/fl Foxp3-Cre,
and Prdm1 (Blimp1) fl/fl Foxp3-Cre mice to study the reciprocal roles of Bcl6 and Blimp1 in …
regulatory (Tfr) cells that regulate germinal center responses. Bcl6 also affects the function of
regulatory T (Treg) cells. Objective The goal of this study was to define the functions of Bcl6
in Treg cells, including Tfr cells, in the context of allergic airway inflammation. Methods We
used a model of house dust mite sensitization to challenge wild-type, Bcl6 fl/fl Foxp3-Cre,
and Prdm1 (Blimp1) fl/fl Foxp3-Cre mice to study the reciprocal roles of Bcl6 and Blimp1 in …