Acetylcholine muscarinic M4 receptors as a therapeutic target for alcohol use disorder: converging evidence from humans and rodents
Background Alcohol use disorder (AUD) is a major socioeconomic burden on society, and
current pharmacotherapeutic treatment options are inadequate. Aberrant alcohol use and
seeking alters frontostriatal function. Methods We performed genome-wide RNA sequencing
and subsequent quantitative polymerase chain reaction and receptor binding validation in
the caudate–putamen of human AUD samples to identify potential therapeutic targets. We
then back-translated our top candidate targets into a rodent model of long-term alcohol …
current pharmacotherapeutic treatment options are inadequate. Aberrant alcohol use and
seeking alters frontostriatal function. Methods We performed genome-wide RNA sequencing
and subsequent quantitative polymerase chain reaction and receptor binding validation in
the caudate–putamen of human AUD samples to identify potential therapeutic targets. We
then back-translated our top candidate targets into a rodent model of long-term alcohol …