[HTML][HTML] Ethanol affects striatal interneurons directly and projection neurons through a reduction in cholinergic tone

CP Blomeley, S Cains, R Smith, E Bracci - Neuropsychopharmacology, 2011 - nature.com
CP Blomeley, S Cains, R Smith, E Bracci
Neuropsychopharmacology, 2011nature.com
The acute effects of ethanol on the neurons of the striatum, a basal ganglia nucleus crucially
involved in motor control and action selection, were investigated using whole-cell
recordings. An intoxicating concentration of ethanol (50 mM) produced inhibitory effects on
striatal large aspiny cholinergic interneurons (LAIs) and low-threshold spike interneurons
(LTSIs). These effects persisted in the presence of tetrodotoxin and were because of an
increase in potassium currents, including those responsible for medium and slow …
Abstract
The acute effects of ethanol on the neurons of the striatum, a basal ganglia nucleus crucially involved in motor control and action selection, were investigated using whole-cell recordings. An intoxicating concentration of ethanol (50 mM) produced inhibitory effects on striatal large aspiny cholinergic interneurons (LAIs) and low-threshold spike interneurons (LTSIs). These effects persisted in the presence of tetrodotoxin and were because of an increase in potassium currents, including those responsible for medium and slow afterhyperpolarizations. In contrast, fast-spiking interneurons (FSIs) were directly excited by ethanol, which depolarized these neurons through the suppression of potassium currents. Medium spiny neurons (MSNs) became hyperpolarized in the presence of ethanol, but this effect did not persist in the presence of tetrodotoxin and was mimicked and occluded by application of the M1 muscarinic receptor antagonist telenzepine. Ethanol effects on MSNs were also abolished by 100 μM barium. This showed that the hyperpolarizations observed in MSNs were because of decreased tonic activation of M1 muscarinic receptors, resulting in an increase in Kir2 conductances. Evoked GABAergic responses of MSNs were reversibly decreased by ethanol with no change in paired-pulse ratio. Furthermore, ethanol impaired the ability of thalamostriatal inputs to inhibit a subsequent corticostriatal glutamatergic response in MSNs. These results offer the first comprehensive description of the highly cell type-specific effects of ethanol on striatal neurons and provide a cellular basis for the interpretation of ethanol influence on a brain area crucially involved in the motor and decisional impairment caused by this drug.
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