[HTML][HTML] Glycogen synthase kinase 3β: a novel marker and modulator of inflammatory injury in chronic renal allograft disease
R Gong, Y Ge, S Chen, E Liang, A Esparza… - American Journal of …, 2008 - Elsevier
One key cell-signaling event central to inflammation in kidney diseases, including chronic
renal allograft dysfunction or disease (CRAD), is the activation of NF-κB, which controls
transcription of numerous proinflammatory mediators. Glycogen synthase kinase (GSK) 3β is
an indispensable element of NF-κB activation, however, the exact role of GSK3β in the
pathogenesis of inflammatory kidney diseases like CRAD is uncertain and was examined.
Immunohistochemistry staining of GSK3β was weak in normal kidneys, but was markedly …
renal allograft dysfunction or disease (CRAD), is the activation of NF-κB, which controls
transcription of numerous proinflammatory mediators. Glycogen synthase kinase (GSK) 3β is
an indispensable element of NF-κB activation, however, the exact role of GSK3β in the
pathogenesis of inflammatory kidney diseases like CRAD is uncertain and was examined.
Immunohistochemistry staining of GSK3β was weak in normal kidneys, but was markedly …