[HTML][HTML] Phosphorylation of p16INK4ACorrelates with Cdk4 Association
J Gump, D Stokoe, F McCormick - Journal of Biological Chemistry, 2003 - ASBMB
Progression through the eukaryotic cell cycle is driven by the activity of cyclin-dependent
kinases. The cyclin D-dependent kinase Cdk4 promotes progression through the G 1 phase
of the cell cycle and is deregulated in many human tumors. The tumor suppressor protein
p16 INK4A (p16) forms a complex with Cdk4 and inhibits kinase activity. Here we report that
p16 is phosphorylated, and the phosphorylated form of p16 is preferentially associated with
Cdk4 in normal human fibroblasts. We mapped phosphorylation sites on exogenously …
kinases. The cyclin D-dependent kinase Cdk4 promotes progression through the G 1 phase
of the cell cycle and is deregulated in many human tumors. The tumor suppressor protein
p16 INK4A (p16) forms a complex with Cdk4 and inhibits kinase activity. Here we report that
p16 is phosphorylated, and the phosphorylated form of p16 is preferentially associated with
Cdk4 in normal human fibroblasts. We mapped phosphorylation sites on exogenously …