Pedigree genetics and environment modulate the biological process of aging. The
permanent and irreversible growth arrest of cell senescence is a central paradigm of aging.
Various pathophysiologic pressures such as oxidative stress and mitochondrial injury can
also induce senescence. Senescent cells secrete altered levels of growth factors, show
increased susceptibility to apoptosis, and associate with delayed repair and regeneration in
the aging kidney. Here we discuss new progress in understanding renal aging, focusing on …