Steroid receptor coactivator 1 (SRC-1) is a transcriptional coactivator not only for steroid
receptors, such as androgen receptor and estrogen receptor, but also for other transcription
factors. SRC-1 has been shown to play an important role in the progression of breast cancer
and prostate cancer. However, its role in liver cancer progression remains unknown. In this
study, we report that SRC-1 was overexpressed in 25 (62.5%) of 40 human hepatocellular
carcinoma (HCC) specimens. Down-regulation of SRC-1 decreased HCC cell proliferation …