Frequent β-catenin aberration in human hepatocellular carcinoma
H Fujie, K Moriya, Y Shintani, T Tsutsumi… - Hepatology …, 2001 - Elsevier
Recently, mutations in the β-catenin gene in hepatocellular carcinoma (HCC) have been
reported: approximately 20% of HCCs had activating mutations at the glycogen synthase
kinase 3β phosphorylation sites within the exon 3 of the β-catenin gene. However, changes
in the level of the β-catenin protein in HCC have not been well studied. We examined, by
Western blotting, the expression level of the β-catenin protein in cancerous tissues in
comparison with that in adjacent non-cancerous tissues obtained from 32 cases of HCC with …
reported: approximately 20% of HCCs had activating mutations at the glycogen synthase
kinase 3β phosphorylation sites within the exon 3 of the β-catenin gene. However, changes
in the level of the β-catenin protein in HCC have not been well studied. We examined, by
Western blotting, the expression level of the β-catenin protein in cancerous tissues in
comparison with that in adjacent non-cancerous tissues obtained from 32 cases of HCC with …