Beta-catenin–NF-κB interactions in murine hepatocytes: A complex to die for
K Nejak-Bowen, A Kikuchi, SPS Monga - Hepatology, 2013 - journals.lww.com
Wnt/β-catenin signaling plays an important role in hepatic homeostasis, especially in liver
development, regeneration, and cancer, and loss of β-catenin signaling is often associated
with increased apoptosis. To elucidate how β-catenin may be regulating hepatocyte survival,
we investigated the susceptibility of β-catenin conditional knockout (KO) mice and their wild-
type (WT) littermates to Fas and tumor necrosis factor-α (TNF-α), two common pathways of
hepatocyte apoptosis. While comparable detrimental effects from Fas activation were …
development, regeneration, and cancer, and loss of β-catenin signaling is often associated
with increased apoptosis. To elucidate how β-catenin may be regulating hepatocyte survival,
we investigated the susceptibility of β-catenin conditional knockout (KO) mice and their wild-
type (WT) littermates to Fas and tumor necrosis factor-α (TNF-α), two common pathways of
hepatocyte apoptosis. While comparable detrimental effects from Fas activation were …
