[HTML][HTML] Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells
F Re, JL Strominger - Journal of Biological Chemistry, 2001 - ASBMB
Toll-like receptors (TLRs) mediate cell activation by various microbial products. Here, we
demonstrate that activation of dendritic cells by TLR2 or TLR4 agonists, although it led to
comparable activation of NF-κB and mitogen-activated protein kinase (MAPK) family
members, resulted in striking differences in cytokine and chemokine gene transcription,
suggesting that TLR2 and TLR4 signaling is not equivalent. A TLR4 agonist specifically
promoted the production of the Th1-inducing cytokine interleukin (IL) 12 p70 and the …
demonstrate that activation of dendritic cells by TLR2 or TLR4 agonists, although it led to
comparable activation of NF-κB and mitogen-activated protein kinase (MAPK) family
members, resulted in striking differences in cytokine and chemokine gene transcription,
suggesting that TLR2 and TLR4 signaling is not equivalent. A TLR4 agonist specifically
promoted the production of the Th1-inducing cytokine interleukin (IL) 12 p70 and the …