An interferon-γ-producing Th1 subset is the major source of IL-17 in experimental autoimmune encephalitis

S Suryani, I Sutton - Journal of neuroimmunology, 2007 - Elsevier
ThIL-17 (IL-17+/IFN-γ−) cell lines are significantly more encephalitogenic than Th1 (IL-
17−/IFN-γ+) cell lines in adoptive transfer EAE models. In actively induced EAE short ex vivo
peptide stimulation identifies an IL-17+/IFN-γ+ population of CD4+ CNS-infiltrating MOG35–
55-specific T cells, which outnumber IL-17+/IFN-γ− cells by approximately 3: 1 as disease
develops. A decrease in numbers of IL-17+/IFN-γ+ cells following in vitro culture is
accompanied by an increase in IL-17−/IFN-γ+ cell numbers. Together these ex vivo and in …