Effects of KDT501 on metabolic parameters in insulin-resistant prediabetic humans
PA Kern, BS Finlin, D Ross, T Boyechko… - Journal of the …, 2017 - academic.oup.com
PA Kern, BS Finlin, D Ross, T Boyechko, B Zhu, N Grayson, R Sims, JS Bland
Journal of the Endocrine Society, 2017•academic.oup.comContext: KDT501 is an isohumulone drug that has demonstrated beneficial effects on
metabolic parameters in mice. Objective: This study was intended to examine potential
improvements in metabolism in humans. Design and Setting: Changes in carbohydrate and
lipid metabolism, along with inflammatory markers, were evaluated in prediabetic humans in
a clinical research center. Participants: Nine obese patients participated. All had prediabetes
or normal glucose tolerance plus three features of metabolic syndrome. Intervention: All …
metabolic parameters in mice. Objective: This study was intended to examine potential
improvements in metabolism in humans. Design and Setting: Changes in carbohydrate and
lipid metabolism, along with inflammatory markers, were evaluated in prediabetic humans in
a clinical research center. Participants: Nine obese patients participated. All had prediabetes
or normal glucose tolerance plus three features of metabolic syndrome. Intervention: All …
Context
KDT501 is an isohumulone drug that has demonstrated beneficial effects on metabolic parameters in mice.
Objective
This study was intended to examine potential improvements in metabolism in humans.
Design and Setting
Changes in carbohydrate and lipid metabolism, along with inflammatory markers, were evaluated in prediabetic humans in a clinical research center.
Participants
Nine obese patients participated. All had prediabetes or normal glucose tolerance plus three features of metabolic syndrome.
Intervention
All participants were treated with escalating doses of KDT501 to a maximum dose of 1000 mg every 12 hours for a total of 28 days.
Outcome Measures
Changes in carbohydrate metabolism were measured with oral glucose tolerance, homeostatic model of insulin resistance, and euglycemic clamp; changes in plasma lipids and response to a lipid tolerance test; and changes in plasma inflammatory markers.
Results
The drug was well tolerated. After KDT501 treatment, plasma triglycerides were reduced at 4 hours during a lipid tolerance test. Furthermore, plasma adiponectin and high-molecular-weight adiponectin increased significantly, and plasma tumor necrosis factor-α decreased significantly. There were no significant changes in oral glucose tolerance test results or insulin sensitivity measures.
Conclusions
Despite the small sample size and the short duration of therapy, KDT501 administration reduced measures of systemic inflammation and improved postmeal plasma triglyceride levels, which may be beneficial in participants with insulin resistance or metabolic syndrome.
Oxford University Press