Bedtime dosing of antihypertensive medications reduces cardiovascular risk in CKD
RC Hermida, DE Ayala, A Mojon… - Journal of the American …, 2011 - journals.lww.com
Time of ingestion of hypertension medications can affect circadian patterns of BP, but
whether this translates into an effect on clinical outcomes is unknown. Here, in an open-
label trial, we randomly assigned 661 patients with CKD either to take all prescribed
hypertension medications upon awakening or to take at least one of them at bedtime. We
measured 48-hour ambulatory BP at baseline and 3 months after any adjustment in
treatment or, at the least, annually. After a median follow-up of 5.4 years, patients who took …
whether this translates into an effect on clinical outcomes is unknown. Here, in an open-
label trial, we randomly assigned 661 patients with CKD either to take all prescribed
hypertension medications upon awakening or to take at least one of them at bedtime. We
measured 48-hour ambulatory BP at baseline and 3 months after any adjustment in
treatment or, at the least, annually. After a median follow-up of 5.4 years, patients who took …