Age as a determinant of renal sodium conservation in normal man

M Epstein, NK Hollenberg - The Journal of laboratory and …, 1976 - translationalres.com
Age modifies a number of factors which determine renal sodium handling including the rate
of glomerular filtration, renal hemodynamics, and the responsiveness of the renin-
angiotensin-aldosterone system. This study was carried out, therefore, to examine the effects
of age on the capacity of the normal human kidney to respond to restriction of sodium intake.
Renal conservation of sodium and response to dietary sodium restriction was assessed in
89 healthy subjects who were free of cardiovascular, renal, or adrenal disease. The daily …