[HTML][HTML] Hyaluronan facilitates transforming growth factor-β1-dependent proliferation via CD44 and epidermal growth factor receptor interaction
S Meran, DD Luo, R Simpson, J Martin, A Wells… - Journal of Biological …, 2011 - ASBMB
Fibroblast proliferation is an early feature of progressive tissue fibrosis and is largely
regulated by the cytokine transforming growth factor-β1 (TGF-β1). In the oral mucosa,
fibroblasts have a unique phenotype and demonstrate healing with no fibrosis/scarring. Our
previous studies show that whereas dermal fibroblasts proliferate in response to TGF-β1,
oral fibroblasts have an antiproliferative response to this cytokine. Hyaluronan (HA) was
directly linked to this TGF-β1-dependent response. The aim of this study was to understand …
regulated by the cytokine transforming growth factor-β1 (TGF-β1). In the oral mucosa,
fibroblasts have a unique phenotype and demonstrate healing with no fibrosis/scarring. Our
previous studies show that whereas dermal fibroblasts proliferate in response to TGF-β1,
oral fibroblasts have an antiproliferative response to this cytokine. Hyaluronan (HA) was
directly linked to this TGF-β1-dependent response. The aim of this study was to understand …