[HTML][HTML] Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-β signaling
S Souchelnytskyi, K Tamaki, U Engström… - Journal of Biological …, 1997 - ASBMB
Members of the Smad family of intracellular signal transducers are essential for transforming
growth factor-β (TGF-β) to exert its multifunctional effects. After activation of TGF-β receptors,
Smad2 and Smad3 become phosphorylated and form heteromeric complexes with Smad4.
Thereafter, these activated Smad complexes translocate to the nucleus, where they may
direct transcriptional responses. Here we report that TGF-β mediates phosphorylation of
Smad2 at two serine residues in the C terminus, ie Ser 465 and Ser 467, which are …
growth factor-β (TGF-β) to exert its multifunctional effects. After activation of TGF-β receptors,
Smad2 and Smad3 become phosphorylated and form heteromeric complexes with Smad4.
Thereafter, these activated Smad complexes translocate to the nucleus, where they may
direct transcriptional responses. Here we report that TGF-β mediates phosphorylation of
Smad2 at two serine residues in the C terminus, ie Ser 465 and Ser 467, which are …