[HTML][HTML] Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells
A Hollnagel, V Oehlmann, J Heymer, U Rüther… - Journal of Biological …, 1999 - ASBMB
Bone morphogenetic proteins (BMPs) are morphogenetic signaling molecules essential for
embryonic patterning. To obtain molecular insight into the influence of BMPs on
morphogenesis, we searched for new genes directly activated by BMP signaling. In vitro
cultured mouse embryonic stem (ES) cells were used, cultivated in chemically defined
growth medium (CDM). CDM-cultured ES cells responded very selectively to stimulation by
various mesoderm inducers (BMP2/4, activin A, and basic fibroblast growth factor). BMP2/4 …
embryonic patterning. To obtain molecular insight into the influence of BMPs on
morphogenesis, we searched for new genes directly activated by BMP signaling. In vitro
cultured mouse embryonic stem (ES) cells were used, cultivated in chemically defined
growth medium (CDM). CDM-cultured ES cells responded very selectively to stimulation by
various mesoderm inducers (BMP2/4, activin A, and basic fibroblast growth factor). BMP2/4 …