[HTML][HTML] Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase
N Machida, M Umikawa, K Takei, N Sakima… - Journal of Biological …, 2004 - ASBMB
Little is known about the specific signaling roles of Rap2, a Ras family small GTP-binding
protein. In a search for novel Rap2-interacting proteins by the yeast two-hybrid system, we
isolated isoform 3 of the human mitogen-activated protein kinase kinase kinase kinase 4
(MAP4K4), a previously described but uncharacterized isoform. Other isoforms of MAP4K4
in humans and mice are known as hematopoietic progenitor kinase (HPK)/germinal center
kinase (GCK)-like kinase and Nck-interacting kinase, respectively. MAP4K4 belongs to the …
protein. In a search for novel Rap2-interacting proteins by the yeast two-hybrid system, we
isolated isoform 3 of the human mitogen-activated protein kinase kinase kinase kinase 4
(MAP4K4), a previously described but uncharacterized isoform. Other isoforms of MAP4K4
in humans and mice are known as hematopoietic progenitor kinase (HPK)/germinal center
kinase (GCK)-like kinase and Nck-interacting kinase, respectively. MAP4K4 belongs to the …