[HTML][HTML] The Traf2-and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton
K Taira, M Umikawa, K Takei, BE Myagmar… - Journal of Biological …, 2004 - ASBMB
Rap2 belongs to the Ras family of small GTP-binding proteins, but its specific roles in cell
signaling remain unknown. In the present study, we have affinity-purified from rat brain a
Rap2-interacting protein of∼ 155 kDa, p155. By liquid chromatography tandem mass
spectrometry, we have identified p155 as Traf2-and Nck-interacting kinase (TNIK). TNIK
possesses an N-terminal kinase domain homologous to STE20, the Saccharomyces
cerevisiae mitogen-activated protein kinase kinase kinase kinase, and a C-terminal …
signaling remain unknown. In the present study, we have affinity-purified from rat brain a
Rap2-interacting protein of∼ 155 kDa, p155. By liquid chromatography tandem mass
spectrometry, we have identified p155 as Traf2-and Nck-interacting kinase (TNIK). TNIK
possesses an N-terminal kinase domain homologous to STE20, the Saccharomyces
cerevisiae mitogen-activated protein kinase kinase kinase kinase, and a C-terminal …