Energy Metabolism in Human Obesity: Plasma Free Fatty Acid, Glucose, and Glycerol Response to Epinephrine
M Goldberg, ES Gordon - Jama, 1964 - jamanetwork.com
ABNORMALLY HIGH fasting levels of plasma free fatty acids (FFA) and decreased
responsiveness of this lipid fraction to various lipolytic stimuli in obese humans and animals
have now been documented by several investigators. 1-5 Whether such alterations in FFA
metabolism relate to obesity as cause or effect, however, remains speculative. We have
previously reported the failure of the plasma FFA to rise significantly during periods of
prolonged fasting in certain patients with longstanding, therapeutically resistant obesity. 1 In …
responsiveness of this lipid fraction to various lipolytic stimuli in obese humans and animals
have now been documented by several investigators. 1-5 Whether such alterations in FFA
metabolism relate to obesity as cause or effect, however, remains speculative. We have
previously reported the failure of the plasma FFA to rise significantly during periods of
prolonged fasting in certain patients with longstanding, therapeutically resistant obesity. 1 In …