The many faces of calcineurin inhibitor toxicity—What the FK?
Calcineurin inhibitors (CNIs) are both the savior and Achilles' heel of kidney transplantation.
Although CNIs have significantly reduced rates of acute rejection, their numerous toxicities
can plague kidney transplant recipients. By 10 years, virtually all allografts will have
evidence of CNI nephrotoxicity. CNIs have been strongly associated with hypertension,
dyslipidemia, and new onset of diabetes after transplantation—significantly contributing to
cardiovascular risk in the kidney transplant recipient. Multiple electrolyte derangements …
Although CNIs have significantly reduced rates of acute rejection, their numerous toxicities
can plague kidney transplant recipients. By 10 years, virtually all allografts will have
evidence of CNI nephrotoxicity. CNIs have been strongly associated with hypertension,
dyslipidemia, and new onset of diabetes after transplantation—significantly contributing to
cardiovascular risk in the kidney transplant recipient. Multiple electrolyte derangements …