Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
N Bhala, J Emberson, A Merhi, S Abramson… - Lancet (London …, 2013 - europepmc.org
Lancet (London, England), 2013•europepmc.org
Background The vascular and gastrointestinal effects of non-steroidal anti-inflammatory
drugs (NSAIDs), including selective COX-2 inhibitors (coxibs) and traditional non-steroidal
anti-inflammatory drugs (tNSAIDs), are not well characterised, particularly in patients at
increased risk of vascular disease. We aimed to provide such information through meta-
analyses of randomised trials. Methods We undertook meta-analyses of 280 trials of NSAIDs
versus placebo (124,513 participants, 68,342 person-years) and 474 trials of one NSAID …
drugs (NSAIDs), including selective COX-2 inhibitors (coxibs) and traditional non-steroidal
anti-inflammatory drugs (tNSAIDs), are not well characterised, particularly in patients at
increased risk of vascular disease. We aimed to provide such information through meta-
analyses of randomised trials. Methods We undertook meta-analyses of 280 trials of NSAIDs
versus placebo (124,513 participants, 68,342 person-years) and 474 trials of one NSAID …
Background
The vascular and gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors (coxibs) and traditional non-steroidal anti-inflammatory drugs (tNSAIDs), are not well characterised, particularly in patients at increased risk of vascular disease. We aimed to provide such information through meta-analyses of randomised trials.
Methods
We undertook meta-analyses of 280 trials of NSAIDs versus placebo (124,513 participants, 68,342 person-years) and 474 trials of one NSAID versus another NSAID (229,296 participants, 165,456 person-years). The main outcomes were major vascular events (non-fatal myocardial infarction, non-fatal stroke, or vascular death); major coronary events (non-fatal myocardial infarction or coronary death); stroke; mortality; heart failure; and upper gastrointestinal complications (perforation, obstruction, or bleed).
europepmc.org