Polygammaglutamyl metabolites of methotrexate
CM Baugh, CL Krumdieck, MG Nair - Biochemical and biophysical …, 1973 - Elsevier
CM Baugh, CL Krumdieck, MG Nair
Biochemical and biophysical research communications, 1973•ElsevierHeretofore unrecognized metabolites of methotrexate (MTX) have been detected in human
red blood cells and isolated from rat liver and viscera. The metabolites from the rat were
identified as 2, 4-diamino-N 10-methylpteroylglutamyl-γ-glutamic acid [MTX (G 1)] and 2, 4-
diamino-N 10-methylpteroylglutamyl-γ-glutamyl-γ-glutamic acid [MTX (G 2)] by comparison
with authentic synthetic compounds.
red blood cells and isolated from rat liver and viscera. The metabolites from the rat were
identified as 2, 4-diamino-N 10-methylpteroylglutamyl-γ-glutamic acid [MTX (G 1)] and 2, 4-
diamino-N 10-methylpteroylglutamyl-γ-glutamyl-γ-glutamic acid [MTX (G 2)] by comparison
with authentic synthetic compounds.
Abstract
Heretofore unrecognized metabolites of methotrexate (MTX) have been detected in human red blood cells and isolated from rat liver and viscera. The metabolites from the rat were identified as 2,4-diamino-N10-methylpteroylglutamyl-γ-glutamic acid [MTX(G1)] and 2,4-diamino-N10-methylpteroylglutamyl-γ-glutamyl-γ-glutamic acid [MTX(G2)] by comparison with authentic synthetic compounds.
Elsevier