Macrophage-specific inhibition of NF-κB activation reduces foam-cell formation
V Ferreira, KW van Dijk, AK Groen, RM Vos… - Atherosclerosis, 2007 - Elsevier
Accumulation of lipid-laden macrophages is a hallmark of atherosclerosis. The relevance of
the key transcription factor nuclear factor κB (NF-κB) for macrophage-derived foam-cell
formation has not been unequivocally resolved. Transgenic mice lines were generated in
which NF-κB activation is specifically inhibited in macrophages by overexpressing a trans-
dominant, non-degradable form of IκBα (IκBα (32A/36A)) under control of the macrophage-
specific SR-A promoter. Alanine substitution of serines 32 and 36 prevents degradation and …
the key transcription factor nuclear factor κB (NF-κB) for macrophage-derived foam-cell
formation has not been unequivocally resolved. Transgenic mice lines were generated in
which NF-κB activation is specifically inhibited in macrophages by overexpressing a trans-
dominant, non-degradable form of IκBα (IκBα (32A/36A)) under control of the macrophage-
specific SR-A promoter. Alanine substitution of serines 32 and 36 prevents degradation and …