Nuclear factor-κB activation as a pathological mechanism of lipid metabolism and atherosclerosis
XH Yu, XL Zheng, CK Tang - Advances in clinical chemistry, 2015 - Elsevier
Atherosclerosis is a chronic inflammatory disease of the arterial wall with lipid-laden lesions,
involving a complex interaction between multiple different cell types and cytokine networks.
Inflammatory responses mark all stages of atherogenesis: from lipid accumulation in the
intima to plaque formation and eventual rupture. One of the most important regulators of
inflammation is the transcription factor nuclear factor-κB (NF-κB), which is activated through
the canonical and noncanonical pathways in response to various stimuli. NF-κB has long …
involving a complex interaction between multiple different cell types and cytokine networks.
Inflammatory responses mark all stages of atherogenesis: from lipid accumulation in the
intima to plaque formation and eventual rupture. One of the most important regulators of
inflammation is the transcription factor nuclear factor-κB (NF-κB), which is activated through
the canonical and noncanonical pathways in response to various stimuli. NF-κB has long …