A brief history of autophagy from cell biology to physiology and disease

N Mizushima - Nature cell biology, 2018 - nature.com
Nature cell biology, 2018nature.com
The field of autophagy research has developed rapidly since the first description of the
process in the 1960s and the identification of autophagy genes in the 1990s. Autophagy is
now increasingly studied at the level of organismal pathophysiology and is being connected
to the medical sciences. This Historical Perspective describes a brief history of autophagy
and discusses unanswered cell biological questions in the field.
Abstract
The field of autophagy research has developed rapidly since the first description of the process in the 1960s and the identification of autophagy genes in the 1990s. Autophagy is now increasingly studied at the level of organismal pathophysiology and is being connected to the medical sciences. This Historical Perspective describes a brief history of autophagy and discusses unanswered cell biological questions in the field.
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