RNA-quality control by the exosome
Nature reviews Molecular cell biology, 2006•nature.com
The exosome complex of 3′→ 5′ exonucleases is an important component of the RNA-
processing machinery in eukaryotes. This complex functions in the accurate processing of
nuclear RNA precursors and in the degradation of RNAs in both the nucleus and the
cytoplasm. However, it has been unclear how different classes of substrate are distinguished
from one another. Recent studies now provide insights into the regulation and structure of
the exosome, and they reveal striking similarities between the process of RNA degradation …
processing machinery in eukaryotes. This complex functions in the accurate processing of
nuclear RNA precursors and in the degradation of RNAs in both the nucleus and the
cytoplasm. However, it has been unclear how different classes of substrate are distinguished
from one another. Recent studies now provide insights into the regulation and structure of
the exosome, and they reveal striking similarities between the process of RNA degradation …
Abstract
The exosome complex of 3′→5′ exonucleases is an important component of the RNA-processing machinery in eukaryotes. This complex functions in the accurate processing of nuclear RNA precursors and in the degradation of RNAs in both the nucleus and the cytoplasm. However, it has been unclear how different classes of substrate are distinguished from one another. Recent studies now provide insights into the regulation and structure of the exosome, and they reveal striking similarities between the process of RNA degradation in bacteria and eukaryotes.
nature.com