Purpose: Hypoxia shifts the balance of cellular energy production toward glycolysis with
lactate generation as a by-product. Quantitative bioluminescence imaging allows for the
quantitation of lactate concentrations in individual tumors. We assessed the relationship
between pretreatment tumor lactate concentrations and subsequent development of
metastatic disease in patients with newly diagnosed head-and-neck cancer. Methods and
Materials: At the time of biopsy of the primary site, a separate specimen was taken and flash …