Requirement of CD30 expression on CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis

K Shinoda, X Sun, A Oyamada, H Yamada… - Journal of …, 2016 - Elsevier
CD30, a member of the tumor necrosis factor receptor superfamily, is expressed
preferentially by effector or memory helper T cells. Here we show that experimental
autoimmune encephalomyelitis (EAE) is ameliorated with markedly reduced induction of
antigen-specific Th1 and Th17 cells in CD30 knockout mice. Passive EAE indicated that
CD30 on non-hematopoietic parenchymal cell is not required and mixed bone marrow
chimera experiments revealed that CD30 signaling on CD4 T cells amplified the …