Aging has multifaceted effects on the immune system, but how aging affects tissue-specific
immunity is not well-defined. Bladder diseases characterized by chronic inflammation are
highly prevalent in older women, but mechanisms by which aging promotes these
pathologies remain unknown. Tissue transcriptomics of unperturbed, young and aged
bladders identified a highly altered immune landscape as a fundamental feature of the aging
female bladder. Detailed mapping of immune cells using single cell RNA-sequencing …