Role of CD30+ T cells in rheumatoid arthritis: a counter-regulatory paradigm for Th1-driven diseases
TRENDS in Immunology, 2001•cell.com
CD30 has been proposed to identify Th0/2-type clones. However, the in vivo relevance of
this finding is still a matter of debate, as high serum levels of soluble CD30 have been found
in both Th1-and Th2-dominated disorders. Among these, rheumatoid arthritis represents a
condition where the Th1 predominance is combined with the presence of CD30+ T-cell
activity, particularly in specific stages of the disease. This article discusses the hypothesis
that CD30+ T cells might play a counter-regulatory role at sites of inflammation in Th1 …
this finding is still a matter of debate, as high serum levels of soluble CD30 have been found
in both Th1-and Th2-dominated disorders. Among these, rheumatoid arthritis represents a
condition where the Th1 predominance is combined with the presence of CD30+ T-cell
activity, particularly in specific stages of the disease. This article discusses the hypothesis
that CD30+ T cells might play a counter-regulatory role at sites of inflammation in Th1 …
Abstract
CD30 has been proposed to identify Th0/2-type clones. However, the in vivo relevance of this finding is still a matter of debate, as high serum levels of soluble CD30 have been found in both Th1- and Th2- dominated disorders. Among these, rheumatoid arthritis represents a condition where the Th1 predominance is combined with the presence of CD30+ T-cell activity, particularly in specific stages of the disease. This article discusses the hypothesis that CD30+ T cells might play a counter-regulatory role at sites of inflammation in Th1-mediated conditions, such as rheumatoid arthritis.
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