[HTML][HTML] ApoA5 lowers triglyceride levels via suppression of ANGPTL3/8-mediated LPL inhibition
YQ Chen, TG Pottanat, EY Zhen, RW Siegel… - Journal of Lipid …, 2021 - ASBMB
Triglyceride (TG) molecules represent the major storage form of fatty acids, and TG
metabolism is essential to human health. However, the mechanistic details surrounding TG
metabolism are complex and incompletely elucidated. Although it is known that angiopoietin-
like protein 8 (ANGPTL8) increases TGs through an ANGPTL3/8 complex that inhibits LPL,
the mechanism governing ApoA5, which lowers TGs, has remained elusive. Current
hypotheses for how ApoA5 acts include direct stimulation of LPL, facilitation of TG …
metabolism is essential to human health. However, the mechanistic details surrounding TG
metabolism are complex and incompletely elucidated. Although it is known that angiopoietin-
like protein 8 (ANGPTL8) increases TGs through an ANGPTL3/8 complex that inhibits LPL,
the mechanism governing ApoA5, which lowers TGs, has remained elusive. Current
hypotheses for how ApoA5 acts include direct stimulation of LPL, facilitation of TG …