Effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk: the STRENGTH randomized clinical …
SJ Nicholls, AM Lincoff, M Garcia, D Bash… - Jama, 2020 - jamanetwork.com
Importance It remains uncertain whether the omega-3 fatty acids eicosapentaenoic acid
(EPA) and docosahexaenoic acid (DHA) reduce cardiovascular risk. Objective To determine
the effects on cardiovascular outcomes of a carboxylic acid formulation of EPA and DHA
(omega-3 CA) with documented favorable effects on lipid and inflammatory markers in
patients with atherogenic dyslipidemia and high cardiovascular risk. Design, Setting, and
Participants A double-blind, randomized, multicenter trial (enrollment October 30, 2014, to …
(EPA) and docosahexaenoic acid (DHA) reduce cardiovascular risk. Objective To determine
the effects on cardiovascular outcomes of a carboxylic acid formulation of EPA and DHA
(omega-3 CA) with documented favorable effects on lipid and inflammatory markers in
patients with atherogenic dyslipidemia and high cardiovascular risk. Design, Setting, and
Participants A double-blind, randomized, multicenter trial (enrollment October 30, 2014, to …