[HTML][HTML] Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance
RC Adam, IJ Mintah, CA Alexa-Braun… - Journal of lipid …, 2020 - ASBMB
Angiopoietin-like protein (ANGPTL) 3 regulates plasma lipids by inhibiting LPL and
endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical
LDLR-mediated pathway and represents a promising therapeutic approach for individuals
with homozygous familial hypercholesterolemia due to LDLR mutations. Yet, how ANGPTL3
regulates LDL-C levels is unknown. Here, we demonstrate in hyperlipidemic humans and
mice that ANGPTL3 controls VLDL catabolism upstream of LDL. Using kinetic, lipidomic, and …
endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical
LDLR-mediated pathway and represents a promising therapeutic approach for individuals
with homozygous familial hypercholesterolemia due to LDLR mutations. Yet, how ANGPTL3
regulates LDL-C levels is unknown. Here, we demonstrate in hyperlipidemic humans and
mice that ANGPTL3 controls VLDL catabolism upstream of LDL. Using kinetic, lipidomic, and …