Nicotinamide inhibits corneal endothelial mesenchymal transition and accelerates wound healing
Z Li, H Duan, W Li, Y Jia, S Zhang, C Zhao… - Experimental eye …, 2019 - Elsevier
Corneal endothelial cells (CECs) maintain the clarity of the cornea through the barrier and
pump function. Ex vivo culture or injury may cause corneal endothelial-mesenchymal
transition (EnMT) and lead to loss of function. In this study, we explored the effects of
nicotinamide (NIC) on the wound healing of rabbit corneal endothelium and the proliferation,
migration, and EnMT of cultured human CEC lines. The animal results showed that corneal
clarity was rapidly recovered within seven days through topical application of NIC in the …
pump function. Ex vivo culture or injury may cause corneal endothelial-mesenchymal
transition (EnMT) and lead to loss of function. In this study, we explored the effects of
nicotinamide (NIC) on the wound healing of rabbit corneal endothelium and the proliferation,
migration, and EnMT of cultured human CEC lines. The animal results showed that corneal
clarity was rapidly recovered within seven days through topical application of NIC in the …