[PDF][PDF] Uncovering metabolic bottlenecks in KEAP1 mutant lung cancer
SE LeBoeuf, W Wu, T Karakousi, R Wild… - Cancer …, 2020 - dracenpharma.com
Cancer Res, 2020•dracenpharma.com
During tumorigenesis, cancer cells continuously encounter metabolic bottlenecks as a result
of accelerated growth, overall increased metabolic demand and increased oxidative stress
due to the formation of reactive oxygen species (ROS). Lung cancer, the leading cause of
cancer-related deaths worldwide, is the most common cancer type to acquire mutually
exclusive gain-of-function mutations in the anti-oxidant transcription factor NRF2 or loss-of-
function mutations in its negative regulator KEAP1. Loss of Keap1 activates Nrf2, increases …
of accelerated growth, overall increased metabolic demand and increased oxidative stress
due to the formation of reactive oxygen species (ROS). Lung cancer, the leading cause of
cancer-related deaths worldwide, is the most common cancer type to acquire mutually
exclusive gain-of-function mutations in the anti-oxidant transcription factor NRF2 or loss-of-
function mutations in its negative regulator KEAP1. Loss of Keap1 activates Nrf2, increases …
Abstract
During tumorigenesis, cancer cells continuously encounter metabolic bottlenecks as a result of accelerated growth, overall increased metabolic demand and increased oxidative stress due to the formation of reactive oxygen species (ROS). Lung cancer, the leading cause of cancer-related deaths worldwide, is the most common cancer type to acquire mutually exclusive gain-of-function mutations in the anti-oxidant transcription factor NRF2 or loss-of-function mutations in its negative regulator KEAP1. Loss of Keap1 activates Nrf2, increases antioxidant production and dramatically accelerates KRAS-driven lung cancer.
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