Indoleamine 2, 3-dioxygenase and its therapeutic inhibition in cancer
GC Prendergast, WJ Malachowski, A Mondal… - International review of …, 2018 - Elsevier
The tryptophan catabolic enzyme indoleamine 2, 3-dioxygenase-1 (IDO1) has attracted
enormous attention in driving cancer immunosuppression, neovascularization, and
metastasis. IDO1 suppresses local CD8+ T effector cells and natural killer cells and induces
CD4+ T regulatory cells (iTreg) and myeloid-derived suppressor cells (MDSC). The
structurally distinct enzyme tryptophan dioxygenase (TDO) also has been implicated
recently in immune escape and metastatic progression. Lastly, emerging evidence suggests …
enormous attention in driving cancer immunosuppression, neovascularization, and
metastasis. IDO1 suppresses local CD8+ T effector cells and natural killer cells and induces
CD4+ T regulatory cells (iTreg) and myeloid-derived suppressor cells (MDSC). The
structurally distinct enzyme tryptophan dioxygenase (TDO) also has been implicated
recently in immune escape and metastatic progression. Lastly, emerging evidence suggests …