BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells
X Li, HY Yang, CM Giachelli - Atherosclerosis, 2008 - Elsevier
Vascular calcification is associated with increased risk of cardiovascular events that are the
most common cause of death in patients with end-stage renal disease. Clinical and
experimental studies indicate that hyperphosphatemia is a risk factor for vascular
calcification and cardiovascular mortality in these patients. Our previous studies
demonstrated that phosphate transport through the type III sodium-dependent phosphate
cotransporter, Pit-1, was necessary for phosphate-induced calcification and …
most common cause of death in patients with end-stage renal disease. Clinical and
experimental studies indicate that hyperphosphatemia is a risk factor for vascular
calcification and cardiovascular mortality in these patients. Our previous studies
demonstrated that phosphate transport through the type III sodium-dependent phosphate
cotransporter, Pit-1, was necessary for phosphate-induced calcification and …