[HTML][HTML] Bone morphogenetic protein-2 stimulates Runx2 acetylation
EJ Jeon, KY Lee, NS Choi, MH Lee, HN Kim… - Journal of Biological …, 2006 - ASBMB
Runx2/Cbfa1/Pebp2aA is a global regulator of osteogenesis and is crucial for regulating the
expression of bone-specific genes. Runx2 is a major target of the bone morphogenetic
protein (BMP) pathway. Genetic analysis has revealed that Runx2 is degraded through a
Smurf-mediated ubiquitination pathway, and its activity is inhibited by HDAC4. Here, we
demonstrate the molecular link between Smurf, HDACs and Runx2, in BMP signaling. BMP-
2 signaling stimulates p300-mediated Runx2 acetylation, increasing transactivation activity …
expression of bone-specific genes. Runx2 is a major target of the bone morphogenetic
protein (BMP) pathway. Genetic analysis has revealed that Runx2 is degraded through a
Smurf-mediated ubiquitination pathway, and its activity is inhibited by HDAC4. Here, we
demonstrate the molecular link between Smurf, HDACs and Runx2, in BMP signaling. BMP-
2 signaling stimulates p300-mediated Runx2 acetylation, increasing transactivation activity …