[HTML][HTML] BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity
JH Jun, WJ Yoon, SB Seo, KM Woo, GS Kim… - Journal of biological …, 2010 - ASBMB
Runx2 is a critical transcription factor for osteoblast differentiation. Regulation of Runx2
expression levels and transcriptional activity is important for bone morphogenetic protein
(BMP)-induced osteoblast differentiation. Previous studies have shown that extracellular
signal-regulated kinase (Erk) activation enhances the transcriptional activity of Runx2 and
that BMP-induced Runx2 acetylation increases Runx2 stability and transcriptional activity.
Because BMP signaling induces Erk activation in osteoblasts, we sought to investigate …
expression levels and transcriptional activity is important for bone morphogenetic protein
(BMP)-induced osteoblast differentiation. Previous studies have shown that extracellular
signal-regulated kinase (Erk) activation enhances the transcriptional activity of Runx2 and
that BMP-induced Runx2 acetylation increases Runx2 stability and transcriptional activity.
Because BMP signaling induces Erk activation in osteoblasts, we sought to investigate …