The metabolic spectrum of memory T cells
D O'Sullivan - Immunology and Cell Biology, 2019 - Wiley Online Library
D O'Sullivan
Immunology and Cell Biology, 2019•Wiley Online LibraryThe development and persistence of memory T cells are integral to effective host defenses.
Cell metabolism has a central role in the maintenance of these populations and
engagement of specific metabolic pathways can influence T‐cell fate. Nuances in memory T‐
cell metabolism are both context dependent, and exist, on a spectrum that complements and
supports the activity of specific memory T‐cell subsets. This review explores how metabolic
pathways and substrate choice can influence the phenotype and function of memory T cells.
Cell metabolism has a central role in the maintenance of these populations and
engagement of specific metabolic pathways can influence T‐cell fate. Nuances in memory T‐
cell metabolism are both context dependent, and exist, on a spectrum that complements and
supports the activity of specific memory T‐cell subsets. This review explores how metabolic
pathways and substrate choice can influence the phenotype and function of memory T cells.
Abstract
The development and persistence of memory T cells are integral to effective host defenses. Cell metabolism has a central role in the maintenance of these populations and engagement of specific metabolic pathways can influence T‐cell fate. Nuances in memory T‐cell metabolism are both context dependent, and exist, on a spectrum that complements and supports the activity of specific memory T‐cell subsets. This review explores how metabolic pathways and substrate choice can influence the phenotype and function of memory T cells.
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