Development of replication-competent viral vectors for HIV vaccine delivery
CL Parks, LJ Picker, CR King - Current opinion in HIV and AIDS, 2013 - journals.lww.com
CL Parks, LJ Picker, CR King
Current opinion in HIV and AIDS, 2013•journals.lww.comA variety of DNA and RNA viruses are being used to develop replication-competent viral
vectors for HIV vaccine delivery. Multiple viral vector platforms have proven to be well
tolerated and immunogenic with evidence of efficacy in macaques. Some of the more
advanced HIV vaccine prototypes based on vesicular stomatitis virus, vaccinia virus,
measles virus, and Sendai virus are in clinical trials.
vectors for HIV vaccine delivery. Multiple viral vector platforms have proven to be well
tolerated and immunogenic with evidence of efficacy in macaques. Some of the more
advanced HIV vaccine prototypes based on vesicular stomatitis virus, vaccinia virus,
measles virus, and Sendai virus are in clinical trials.
Summary
A variety of DNA and RNA viruses are being used to develop replication-competent viral vectors for HIV vaccine delivery. Multiple viral vector platforms have proven to be well tolerated and immunogenic with evidence of efficacy in macaques. Some of the more advanced HIV vaccine prototypes based on vesicular stomatitis virus, vaccinia virus, measles virus, and Sendai virus are in clinical trials.
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