Human leptin enhances activation and proliferation of human circulating T lymphocytes
C Martín-Romero, J Santos-Alvarez, R Goberna… - Cellular …, 2000 - Elsevier
Leptin is an adipocyte-secreted hormone that centrally regulates weight control. However,
leptin receptor is expressed not only in the central nervous system, but also in other systems
such as reproductive and hematopoietic tissues. Human leptin has previously been shown
to enhance cytokine production by murine peritoneal macrophages and human circulating
monocytes. In this paper we have assessed the presence of leptin receptors in peripheral
human T lymphocytes and we have studied their functional role. Both CD4+ and CD8+ T …
leptin receptor is expressed not only in the central nervous system, but also in other systems
such as reproductive and hematopoietic tissues. Human leptin has previously been shown
to enhance cytokine production by murine peritoneal macrophages and human circulating
monocytes. In this paper we have assessed the presence of leptin receptors in peripheral
human T lymphocytes and we have studied their functional role. Both CD4+ and CD8+ T …