[HTML][HTML] Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases
M Allen, X Wang, JD Burgess, J Watzlawik… - Alzheimer's & …, 2018 - Elsevier
Introduction Comparative transcriptome analyses in Alzheimer's disease (AD) and other
neurodegenerative proteinopathies can uncover both shared and distinct disease pathways.
Methods We analyzed 940 brain transcriptomes including patients with AD, progressive
supranuclear palsy (PSP; a primary tauopathy), and control subjects. Results We identified
transcriptional coexpression networks implicated in myelination, which were lower in PSP
temporal cortex (TCX) compared with AD. Some of these associations were retained even …
neurodegenerative proteinopathies can uncover both shared and distinct disease pathways.
Methods We analyzed 940 brain transcriptomes including patients with AD, progressive
supranuclear palsy (PSP; a primary tauopathy), and control subjects. Results We identified
transcriptional coexpression networks implicated in myelination, which were lower in PSP
temporal cortex (TCX) compared with AD. Some of these associations were retained even …