T cells and IL-17 in lupus nephritis
T Koga, K Ichinose, GC Tsokos - Clinical immunology, 2017 - Elsevier
Systemic lupus erythematosus (SLE) is a complicated autoimmune disorder characterized
by autoantibodies production, immune complex formation, and immune dysregulation,
resulting in damage of multiple organs including the kidney. Lupus nephritis (LN) is the most
common severe manifestation of SLE involving the majority of patients. Even though there
are a number of reports indicating that interleukin-17 (IL-17) and Th17 cells play important
roles in the pathogenesis of LN, the precise molecular mechanisms underline the …
by autoantibodies production, immune complex formation, and immune dysregulation,
resulting in damage of multiple organs including the kidney. Lupus nephritis (LN) is the most
common severe manifestation of SLE involving the majority of patients. Even though there
are a number of reports indicating that interleukin-17 (IL-17) and Th17 cells play important
roles in the pathogenesis of LN, the precise molecular mechanisms underline the …