[HTML][HTML] Regulation of aquaporin-4 water channels by phorbol ester-dependent protein phosphorylation
Z Han, MB Wax, RV Patil - Journal of Biological Chemistry, 1998 - ASBMB
The molecular mechanisms for regulating water balance in many tissues are unknown. Like
the kidney, the eye contains multiple water channel proteins (aquaporins) that transport
water through membranes, including two (AQP1 and AQP4) in the ciliary body, the site of
aqueous humor production. However, because humans with defective AQP1 are
phenotypically normal and because the ocular application of phorbol esters reduce
intraocular pressure, we postulated that the water channel activity of AQP4 may be regulated …
the kidney, the eye contains multiple water channel proteins (aquaporins) that transport
water through membranes, including two (AQP1 and AQP4) in the ciliary body, the site of
aqueous humor production. However, because humans with defective AQP1 are
phenotypically normal and because the ocular application of phorbol esters reduce
intraocular pressure, we postulated that the water channel activity of AQP4 may be regulated …